Monday, December 23, 2019

Platos Laches - 1027 Words

During his lifetime Socrates’ various interactions with his fellow Athenians left his intentions debatable. Popular belief in Athens seemed to be that, â€Å"he [Socrates] was an evildoer, and a curious person, who searches into things under the earth and in heaven ¸ and makes the worse appear the better cause† (Plato, pg. 5) as stated by the unofficial charges against him in The Apology. After discussions, his interlocutor’s were left confused in a state of aporia, with no conclusion. And so while negative views of Socrates became increasing popular in Athens right up until his death, Socrates was, on the contrary, serving as Athens’s benefactor, opening up their eyes to the truth of world in which they lived in. In Plato’s Laches, Socrates†¦show more content†¦However, other Athenians eventually grew tired of Socrates’ extensive questioning and can be seen in The Apology putting Socrates on trial for it. Instead of taking Socrate s’ conversations for what they were worth, they labeled him as argumentative and a man who was corrupting the youth of the city. By breaking down his interlocutors’ various thoughts, ideas, and theses, Socrates was trying to reveal to them that they were not in fact wise and that the knowledge they thought they possessed was not true knowledge. Socrates himself was only considered wiser than his fellow Athenians because he considered his one piece of knowledge to be that he didn’t know anything. By breaking down, piece by piece, the arguments of those he conversed with, he intended for them to realize that their knowledge was relative and therefore meaningless in the grander scheme of things. By recognizing this, only then could they begin living a life in search of finding true meaning. In searching for meaningful things they would have to learn to question things. While he is on trial in The Apology, Socrates tells the jury that, â€Å"The unexamined life is not worth living† (Plato pg. 24) Living life without asking questions, and without inquiry, is not living life at all, and is ther eforeShow MoreRelatedHow Xenophon’s Oeconomicus is a Response to Aristophanes’ Clouds1043 Words   |  5 Pagespresents much of his thought in a manner that requires readers to constantly keep in mind Plato’s thought but also diligently strive to discern Xenophon’s voice. We can easily recognize the relation of Xenophon’s Apology of Socrates to the Jury to Plato’s Apology of Socrates and Xenophon’s Symposium to Plato’s Symposium, and recently it has been proposed that Xenophon’s Education of Cyrus is a direct response to Plato’s Republic exploring grave difficulties Xenophon has with the best regime.1 We may thusRead MoreSocrates s Philosophy And Critical Analysis1138 Words   |  5 PagesDialogues via Plato’s words Socratic dialogues are manifestations of discussions between Socrates and notable men of Athens. These involve a sequel of different questions on themes such as friendship, piety, courage etc. These dialogues serve to be indirect in nature and thus leave the reader to undergo through a catharsis and analyze the beliefs of Socrates. Laches (Courage) This is a dialogue based on strife of two fathers,Lysimachus and Melesias, along with Nicias, Laches, Stesilaus andRead More Plato Essay example1737 Words   |  7 PagesCritias, was the leader of the Thirty Tyrants who were installed in power by the victorious Spartans. One means of perpetuating themselves in power was to implicate as many Athenians as possible in their atrocious acts. Thus Socrates, as we learn in Platos Apology, was ordered to arrest a man and bring him to Athens from Salamis for execution. When the great teacher refused, his life was in jeopardy, and he was probably saved only by the overthrow of the Thirty and the reestablishment of the democracyRead More A life sketch of Plato and his works Essays891 Words   |  4 Pageshis broad shoulders. Plato was born in Athens, Greece to one of the oldest and most distinguished families in the city. He lived with his mother, Perictione, and his father, Ariston (Until Ariston died.) Born in an aristocratic and rich family, Plato’s childhood was indulged within luxury. But his life changed when he came across Socrates. Socrates, a Greek philosopher who lived from 470-399 BC. He devoted all his time with young citizens discussing philosophy and questioning their confidence inRead MorePlato s Views On The Virtue Of The Virtues Essay1256 Words   |  6 Pages(Republic 354c) Plato presents Socrates as believing in the unity of the virtues, skeptical of those who, like Meno, wish to treat the virtues as distinct objects of inquiry in dialogues such as Laches, Protagoras, Meno, the Republic, and Euthyphro. These dialogues provide good reason to deny that Plato’s Socrates believed in the numerical identity of the virtues. I shall argue that in the various virtues is one essence (or ‘virtue’), as revealed in a conceptual search for definitional clarity andRead MoreCan Virtue Be Acquired? An Examination of the Laches, Meno and Protagoras2955 Words   |  12 PagesCan Virtue be Acquired? An Examination of the Laches, Meno, and Protagoras In the Socratic dialogues of Plato, Socrates often argues against the pretence of knowledge in his interlocutors. In the case of the Laches, Meno, and Protagoras dialogues, the pretence is the knowledge of virtue, among other things. The Laches seeks a definition of arà ªte (virtue), the Meno examines the teaching of virtue, and the Protagoras offers a known expert the chance to defend that virtue can, indeed, be taught. UsingRead MoreThe Republic Essay1514 Words   |  7 Pagesboth Solon and Pisistratus. Platos parents were Ariston and Perictone, his older brothers were Adeimantus and Glaucon, and his younger sister was Potone. In keeping with his family heritage, Plato was destined for the political life. But the Peloponnesian War, which began a couple of years before he was born and continued until well after he was twenty, led to the decline of the Athenian Empire. The war was followed by religious movement that led to the execution of Platos mentor, Socrates. TogetherRead Mor e Sport, Education, and the Meaning of Victory Essay examples3416 Words   |  14 Pagessummed up in a word: winning. Is this a sign that we have lost touch with the age-old rationale for including sport in education? I argue that it need not be by showing that we value winning precisely for the virtues associated with it. I then take Platos traditional parts of aretà ª: piety, sophrosunà ª, courage and justice and show how they are manifest in modern athletic ideals of self-knowledge, discipline, courage and justice. To the extent that scholastic athletic programs develop these virtues,Read More Plato on Education as the Development of Reason Essay3512 Words   |  15 Pagesa person never falters to the end of life, this is no more than moral luck. One is still guilty on the level of the logos, and liable to blame and punishment not for what one does, but for what one could have done. The unexamined life, says Platos Socrates, is not worth living for men (Apology 38a5). Two central ideas of Western philosophy came together in this saying, and also a third, Socrates own great innovation. The novelty was not his turning towards man; in this he was but a childRead MoreGreek Philosophers Bible On The Ancient World And English I2969 Words   |  12 Pages Socrates enrolled in the army, fulfilling the position of a hoplite, a type of Greek soldier. He served in Athens military during the Peloponnesian War. Several accounts describe Socrates’ service in the war including writings from Alcibiades, Laches, and Socrates himself. Alcibiades describes how Socrates saved his life in the battle of Potidaea. The trial of Socrates was one of the most controversial trials in the ancient world. Socrates praised Sparta, Athens rival, because of their government

Sunday, December 15, 2019

Herpes Simplex Virus Free Essays

Herpes Simplex Virus Type 1 Infection at the Molecular Level Research Paper Virology 24 November 2008 Abstract Herpes simplex virus type 1 (HSV-1) infection is widespread and causes significant disease in humans. The structure, epidemiology, pathogensis and immune response are examined in this review, as well as specific ways to reduce and eliminate pathology and related diseases. The virus naturally infects mucosal areas and begins the search for its target host cell. We will write a custom essay sample on Herpes Simplex Virus or any similar topic only for you Order Now Upon binding to the host cell membrane via teams of glycoproteins, the virion is then phagocytosed. Soon the nucleus is seized and all regular host cell mechanisms are shut off. Replication of HSV-1 is specific encoding immediate early, early and late genes. Once the virus replication process is complete the virus exits epithelial cells near the site of infection through a process known as cell lysis. Sensory neurons are the specific target of HSV-1, where it can then travel to the trigeminal ganglia (TG) stoma via neuronal microtubular networks. Both innate and adaptive immune systems respond to the infection with various antibodies, interleukins and interferons. Once the virion reaches the nervous system, the immune responses are unable to detect it although they try to contain it as best they can. HSV-1 enters a latent stage, usually via latent associated transcripts, not causing pathogenesis but unable to fight off by means of the host immune system. Following a stressful situation or similarly UV activation, HSV-1 travels back down nerve fibers to re-infect cells near the original site of infection. This process is known to continue throughout the lifespan of the infected individual, normally without fatalities. When the host immune response is unable to contain the virus in the TG, several associated diseases such as encephalitis and keratits result. Genes involved with virus replication and host genes, to eliminate the virus, have been maneuvered to cause reverse effects and are currently used as antivirals. Although no vaccine has been approved for use against HSV-1, various attempts have been made. This research paper defines the virus infection at a molecular level as well as demonstrates modifications of the virus genes to cause reverse effects and investigates just a few of the diseases connected with HSV-1. Introduction Herpes simplex viruses type 1 and 2 are well known members of the family Herpesviridae, subfamily Alphaherpesvirinae, which cause lifelong, latent infection in humans. Herpes simplex virus type 1 (HSV-1) typically remains the cause of cold sores, gingivostomatitis, and skin lesions in the orofacial area, as well as many rare but fatal conditions (1). Herpes simplex virus type 2 (HSV-2) is primarily associated with genital area infection. Worldwide, approximately one third of people display clinical manifestations of HSV-1 infection (2). HSV-1 is neurotropic, infecting multiple cell types but establishing latency in the trigeminal ganglia (TG). HSV-1 reactivates, in response to certain stimuli such as emotional or physical stress or UV light, and is transported along nerve fibers to mucosal or cutaneous regions (1). Infected cells show signs of the nucleus changing shape and nucleolus displacement with a formation of multinucleated giant cells. Cells degenerate, lyse and vesicles of fluid containing the virus locate between the epidermis and dermal layer of the skin forming a lesion (2). Although HSV-1 infects a large percentage of the population, few actually show symptoms of disease. HSV Structure and Genome HSV-1 is an enveloped double stranded DNA (dsDNA) virus consisting of four elements. First, an outer envelope with glycoprotein spikes on its surface. Second, a tegument layer including several viral proteins important during HSV-1 infection. Third, an iscosahedral capsid surrounding the last compartment, the electron opaque core containing the dsDNA genome wrapped as a spool. The envelope is made up of 13 different viral glycoproteins embedded in a lipid bilayer. The viral genome of 152 kb, encode the majority of the proteins of the mature virion. Covalently linked L (long) and S (short) components are broken down into unique long (Ul), flanked by ab and b’a’ repeated segments, and unique short (Us), flanked by ac and c’a’ repeated segments. Homologous recombination between terminal repeats results in four linear isomers at equimolar concentrations (see figure 1). All four isomers, including P (prototype), IL (inversion of the L component), IS (inversion of the S component) and ISL (inversion of both the S and the L component), encode 90 unique transcription genes essential for viral replication (3). HSV Replication Infection is first initialted by the attachment to the host cell glucosaminoglycans, usually heparin sulphate and chondroiton sulphate, with viral glycoprotein C (gC). This bond results in at least five glycoprtoeins, gB, gC, gD, gH and gL, binding to other cell surface receptors, such as Herpesvirus entry mediator or nectin 1? or ? (4). Fusion of the viral envelope follows, and the de-enveloped tegument capsid is transported to the nuclear pores via the microtubular network, where DNA is released into the nucleus. Nuclear pore complex accepts the viral DNA from the capsid, minimizing the diffusion of DNA to the cytoplasm, and the transfer is completed by nuclear pore proteins (5). The viral genome circularizes upon entering the nucleus, and transcription of the five immediate early genes (IE) is done by the host RNA polymerase II. Among the IE genes are ICP0, ICP4, ICP22, ICP27 and ICP47. Host transcription, RNA splicing and transport are inhibited during replication, known as host cell shut off. Early (E) viral genes encode enzymes in nucleotide metabolism and viral DNA replication and require the presence of IE genes. Viral E gene products, including viral DNA polymerase, single-stranded DNA-binding protein, origin binding protein and DNA helicase-primase, assemble on the parental viral DNA and start DNA synthesis in replication compartments. Three DNA replication origins bind by viral origin-binding protein, separate the DNA strands and initiate viral DNA synthesis. Expression of the late (L) genes begins and produces structural components of the virion. Capsid assembly occurs in the cytoplasm and the associated proteins are then transported to the nucleus. Progeny DNA concatamers are cleaved into monomers and are inserted into the capsid. Cleavage and packing of HSV-1 genome requires two cis-acting elements, pac1 and pac2. Next the nucleocapsid matures and egress by passing through the Golgi apparatus with the tegument layer and the virion envelope. (3) HSV Latency After infection of the mucosa or epithelial abrasion, HSV-1 enters sensory neurons near the site of infection and the tegument and nucleocapsid travel by retrograde axonal transport to cell neuronal soma releasing viral DNA and VP16, when the virus may enter lytic replication or the latent state. Lytic replication results in neuronal cell death as described above. (2,3) During latency the genome circularizes and enters a heavily chromatinated state where no infectious virus is produced and the majority of viral gene expression is silenced. Latency associated transcripts (LAT), mRNA genes, are the only transcripts found in latent neurons (6). Expression of LATs is not absolutely required for maintenance of latency. Reactivation triggers the virus to be transported in the opposite direction, antrograde, and re-infection occurs at the initial site of infection. HSV and the Immune System The immune response to HSV-1 includes both innate and adaptive immune responses. Innate immunity is the first line of defense including natural killer (NK) cells, macrophages, dendritic cells, and various cytokines and complement proteins. Initial response involves secreted proteins, such as defensins and complement proteins. Complement proteins bind HSV antigens resulting in the cleavage of complement molecules. This, followed by the formation of the membrane attack complex, destroys the virus. HSV gC blocks the complement cascade, counteracting the effects of complement. The adaptive immune response is triggered with B cell memory enhanced in response to the virus. An antiviral state is induced by infected epithelial cells and resident interferon producing cells (IPCs), secreting interferon ? and ? , priming the surrounding cells for apoptosis. Tumor necrosis factors ? (TNF-? ) is also produced by IPCs and acts as an autocrine signal stimulating differentiation of ICPs to dendritic cells. They can travel to the lymph nodes to stimulate CD4+ T cells to produce IFN-? and interleukin 10 (IL-10). After infection and replication, HSV-1 destroys infected cells and travels to sensory neurons. Polymorphonuclear leukocytes, macrophages, NK and TCR+ T cells infiltrate the TG, control the infection and prevent the spread of the virus to rear by cells, including the brain. The adaptive immune response is driven by the innate immune response. Antigen presenting cells migrate from the site of infection to the regional lymph node to present CD4+ and CD8+ T cells and B cells. Deficient complement cascades leads to less vigorous memory response to HSV-1. Antibodies against gD and the gH-gL complex are found to protect against HSV-1 and are observed as cross reactive to other strains of HSV. Macrophages engulf viral proteins and cell particles from lysed cells and also secrete cytokines favoring the T helper (Th) cell CD4+ response. CD8+ cytoxic T lymphocytes (CTL) are produced and they react with epitopes displayed on infected cells, which are then targeted for apoptosis. See figure 2. The IE protein ICP 27 contains potent CTL epitopes. The efficacy of gB to induce a CTL response suggests gB is the immunodominant antigen of HSV-1. (2) Beneficial Modifications of Genes Associated with Herpes Simplex Virus type 1 and Relative Associated Diseases Occasionally the immune system is unable to prevent HSV-1 from spreading to surrounding structures such as the eye. Ocular HSV-1 infection is termed herpetic keratitis, tissue destruction of the eye, and is currently treated with trifluridine or valacyclovir to inhibit HSV-1 DNA polymerase and terminate synthesis of the sugar backbone of viral DNA. The current antiviral compounds require phosphorylation by the infected cell, meaning the antiviral activity cannot take place until the infection has progressed to the point where specific viral thymidine kinase is synthesized. A new idea involves helicase-primase inhibitors acting to prevent the unwinding of the double-stranded DNA and the initiation of the new strand synthesis necessary for viral production. Kleymann et al. found a compound, BAY 57-1293, more potent and more effective than valacyclovir and unassociated with systemic toxicity to initiate the described mechanism. (7) A similar study explored the lesion associated with the tissue destruction of the cornea, specifically angiogenesis of stromal keratits (SK). The fibroblast growth factor 2 (FGF-2), a molecule known to stimulate cell growth to contribute to wound healing, was targeted to observe the antiviral activity via its effect on HSV-1 cell entry. FGF-2 inhibits HSV-1 from binding to heparin sulfate, thus hindering entrance into the host cell. Results of this study suggest severity and clinical SK could be significantly diminished by daily treatment of lesions with FGF-2 protein, due to accelerated epithelial wound healing. (8) Similarly, HSV-1 can surpass the immune response and travel to the brain. HSV-1 encephalitis is the most devastating consequence of HSV and the most ommon cause of fetal encephalitis. Early growth response 1 (Erg-1) is a zinc finger transcription factor expressed in neural tissue, and is induced during stress. It regulates growth, apoptosis, angiogenesis and development. Erg-1 is known to regulate several viral genes, including LATs, and is inducible by viral proteins. Erg-1 increases viral replication in infe cted cells and mortality in infected mice. Knockout of Erg-1 expression was shown to reduce the mortality by decreasing the viral loads to tissues in a study conducted by Shis-Heng Chen et al. 9) It has been demonstrated HSV-1 can induce increased activity of central norepinephrine or serotonin neurons, by activating the cell bodies located in the brain stem, following encephalitis. Increased brain stem activity of these neurotransmitters can impair glucocorticoids (GC) negative feedback receptors, activating cytokines IL-1 and TNF? , reducing the binding capacity of said GC receptors. Impaired control of the GC negative feedback regulation upon the hypothalamo-pituitary adrenal axis has been suggested as an important aspect in major depression. (10) Thrombin is a result of the generation of sequential proteolytic enzymes activating circular precursor enzymes and cofactors for blood clotting. HSV-1, HSV-2 and cytomegalovirus have been shown to avoid cellular control of coagulation initiation through the constitutive expression of procoagulant phospholipids and tissue factor. This allows the unregulated generation of thrombin because tissue factor can bind ciruculating factor VIIa, forming a cofactor-enzyme complex directly on the virus. ‘Tenase’ activity has been credited to HSV-1 encoded gC, which accelerates the FVIIa-dependent activation of FX. FXa associates with its cofactor V to convert prothrombin to thrombin. Assembly of FX and FV leading to thrombin generation has been demonstrated on the virus surface. Herpes virus genomic material has been associated with atherosclerosis plaque, thrombosis and atherosclerosis due to the unregulated production of thrombin. (11) It is well known NK cells aid in the fight against HSV-1 infection. Severe herpetic infections have been seen in NK -deficient patients, as well as early infiltrations of herpetic lesions by NK cells. This due to damage of HLA class 1 expression by HSV-1 and the lysis of HSV-1 infected targets by NK cells. E. Estefania et al. presented a study suggesting clinical symptoms of HSV-1 infection being more likely to happen among humans expressing the NK cell receptors KIR2DL2 and KIR2DS2. The genes encoding the receptors appear to increase the risk of recurrent infection, where the lack of the receptors is shown to protect from the disease. (1) Conclusion HSV-1 can cause severe recurrent disease in humans and establish lifelong infection in their hosts. Several antiviral approaches have been considered to counteract the effects of HSV-1 throughout the body yet no vaccine, to cure the infection from its host, has been accepted. Acyclovir, and its ester derivative valacyclovir, as well as penciclovir and its prodrug famciclovir, are the latest approved antiviral medications to battle HSV-1 infection. Several other strategies are currently under investigation such as potential therapeutic vaccines, cidofovir, and aqueous extracts in Africa. Past attempts of vaccines have utilized viral vectors, DNA vaccination, recombinant bacteria, cytokines to manipulate the immune response, novel adjuvants, innovative delivery systems and different routes of inoculation. Most of which have been successful in lab mice but none have been approved for human use. Therapeutic vaccines target symptomatic individuals, using DNA vaccines encoding various cytokines used to intentionally bias the immune system toward Th1 or Th2 responses. Different boosts with different cytokine adjuvants may be used to induce proper immune response. (2) Extracts from the eastern cape of Africa, Aloe ferox and Withania somnifera, confirmed morphological changes indicative of cytopathic effects that retard the replication and spread of HSV-1. (12) Furthermore, a hematopoietic stem cell transplant recipient developed mucosal HSV-1 infection, and while under acyclovir treatment, later showed resistance to the antiviral. After developing hemorrhagic cystitis due to polyomavirus BK, cidofovir was prescribed and the patient profited from the broad spectrum anti-DNA virus activity with the disappearance of HSV-1 lesions. (13) In conclusion, as described above the mechanisms by which HSV-1 hijacks and hides out in its host, have been studied to great detail and are routinely manipulated. The particularly complex structure, as well as detailed means by which each gene in the large genome is activated and carries out its genes products, intrigue many scientists which continue to investigate and attempt a formidable vaccine against the virus. Studies among mice have proven effective, although HSV-1 is a very host specific infection, thus making trials of acceptable anitvirals and vaccines extremely difficult. The only slightly acceptable element of HSV-1 infection is, in rare cases where no reoccurrences is shown, and moreover there are many instances of asymptomatic carriers. Devastating incidence such as transferring HSV-1 to a neonate during delivery and schizophrenics showing decreased prefrontal grey matter due to HSV-1, are just a pinch of the terrifying effects of this virus, remaining in host TG until a stressful situation comes along. 14,15) Herpes Simplex Virus type 1 Genome (Figure 1) 00 Herpes Simplex Virus Type 1 Infection (Figure 2) Works Cited 1. )Estefania, E, et al. â€Å"Influence of KIR gene diversity on the course of HSV-1 infection: resistance to the disease is associated with the absence of KIR2DL2 and KIR2DS2. † Tissue Antigens 70. 1 (July 2007): 34-41. MEDLINE. EBSCO. [Library name], [City], [State abbreviation]. 19 Nov. 2008 . 2. )Ferenczy, Michael W. â€Å"Prophylactic Vaccine Strategies and the Potential of Therapeutic Vaccines Against Herpes Simplex Virus. † Current Pharmaceutical Design 13. 9 July 2007): 1975-1988. Academic Search Premier. EBSCO. [Library name], [City], [State abbreviation]. 19 Nov. 2008 . 3. )Shen, Y, and J Nemunaitis.. â€Å"Herpes simplex virus 1 (HSV-1) for cancer treatment. † Cancer Gene Therapy 13. 11 (07 Nov. 2006): 975-992. MEDLINE. EBSCO. [Library name], [City], [State abbreviation]. 19 Nov. 2008 . 4. )Clement, Christian, et al. â€Å"A novel role for phagocytosis-like uptake in herpes simplex virus entry. † Journal of Cell Biology 174. 7 (25 Sep. 2006): 1009-1021. Academic Search Premier. EBSCO. [Library name], [City], [State abbreviation]. 4 Sep. 2008 . 5. )Newcomb, William W, Frank P Booy, and Jay C Brown. â€Å"Uncoating the herpes simplex virus genome. † Journal Of Molecular Biology 370. 4 (20 July 2007): 633-642. MEDLINE. EBSCO. [Library name], [City], [State abbreviation]. 3 Sep. 2008 . 6. )Ramachandran, Srividya, and Paul R Kinchington.. â€Å"Potential prophylactic and therapeutic vaccines for HSV infections. † Current Pharmaceutical Design 13. 19 (2007): 1965-1973. MEDLINE. EBSCO. [Library name], [City], [State abbreviation]. 22 Nov. 2008 . 7. )Kaufman, Herbert E, et al. Efficacy of a helicase-primase inhibitor in animal models of ocular herpes simplex virus type 1 infection. † Journal Of Ocular Pharmacology And Therapeutics: The Official Journal Of The Association For Ocular Pharmacology And Therapeutics 24. 1 (Feb. 2008): 34-42. MEDLINE. EBSCO. [Library name], [City], [State abbreviation]. 19 Nov. 2008 . 8. )Kim, Bumseok, et al. â€Å"Application of FGF-2 to Modulate Herpetic Stromal Keratitis. † Current Eye Research 31. 12 (Dec. 2006): 1021-1028. Academic Search Premier. EBSCO. [Library name], [City], [State abbreviation]. 19 Nov. 2008 . 9. )Chen S, Yao H, Chen I, Shieh B, Li C, Chen S. Suppression of transcription factor early growth response 1 reduces herpes simplex virus lethality in mice. Journal of Clinical Investigation [serial online]. October 2008;118(10):3470-3477. Available from: Academic Search Premier, Ipswich, MA. Accessed November 22, 2008. 10. )Bener, Dafna, et al. â€Å"Glucocorticoid Resistance following Herpes Simplex-1 Infection: Role of Hippocampal Glucocorticoid Receptors. † Neuroendocrinology 85. 4 (Apr. 2007): 207-215. Academic Search Premier. EBSCO. [Library name], [City], [State abbreviation]. 19 Nov. 2008 . 11. )Thrombin paper 12. )Kambizi, L. , et al. Anti-viral effects of aqueous extracts of Aloe Xerox and Withania somnifera on herpes simplex virus type 1 in cell culture. † South African Journal of Science 103. 9/10 (Sep. 2007): 359-360. Academic Search Premier. EBSCO. [Library name], [City], [State abbreviation]. 10 Sep. 2008 . 13. )Andrei, G, et al. â€Å"Dual infection with polyomavirus BK and acyclovir-resistant herpes s implex virus successfully treated with cidofovir in a bone marrow transplant recipient. † Transplant Infectious Disease: An Official Journal Of The Transplantation Society 9. 2 (June 2007): 126-131. MEDLINE. EBSCO. Library name], [City], [State abbreviation]. 19 Nov. 2008 . 14. )Brown, Elizabeth L. , et al. â€Å"Effect of maternal herpes simplex virus (HSV) serostatus and HSV type on risk of neonatal herpes. † Acta Obstetricia Gynecologica Scandinavica 86. 5 (May 2007): 523-529. Academic Search Premier. EBSCO. [Library name], [City], [State abbreviation]. 17 Sep. 2008 . 15. )Prasad, K. M. R. , et al. â€Å"Brain morphological changes associated with exposure to HSV1 in first-episode schizophrenia. † Molecular Psychiatry 12. 1 (Jan. 2007): 105-113. Academic Search Premier. EBSCO. [Library name], [City], [State abbreviation]. 1 Oct. 2008 . How to cite Herpes Simplex Virus, Papers

Saturday, December 7, 2019

Psychodelic Drugs Essay Example For Students

Psychodelic Drugs Essay Psychodelic Drugs AlcoholAlcohol is one of the most widely used drugs in this society. It isaccepted as a part of social life. Its use is widely promoted via sponsorship ofsporting events. Advertising infers that drinking is the path to happiness,success, romance, etc. There are references to alcohol and its effects fromearliest known writings. Alcohol is consumed in the beverage form and soldlegally in this state to persons over 21. Alcohol is absorbed directly into the bloodstream through the stomachand small intestine. It is distributed by the blood throughout the body,affecting literally every organ it touches in a matter of minutes. Enzymes inthe liver metabolize alcohol at a rate of 10-15 ml (less than one half ounce)per hour. Hence, only time can sober someone up. Coffee, cold showers, orexercise do not work. The warm glow of disinhibition, letting go is a major desired effectof alcohol. People feel more sociable and talkative with small amounts of thedrug. Alcohol is a relaxant, so many people drink to unwind from the demands oflife. Because alcohol has been around for so long, its effects are well-known. Two key concepts to understand in dealing with alcohol use and abuse areimpairment and tolerance. They are both problems in themselves and signals ofpossible additional difficulties. IMPAIRMENT refers to the deficits in performance, judgment, memory, andmotor skills which occur because of alcohol consumption. Impairment becomesnoticeable at blood levels of 0.05%, which can occur when as few as two drinksare consumed in an hour by a 160 pound person. The deceptive part aboutimpairment is that, by definition, impaired judgment cannot recognize its ownimpairment. The individual thinks he or she is functioning well, when actuallys/he is not. Later, there is impaired memory of the impaired performance. TOLERANCE means that a drug loses some of its effect with repeated use,and that higher and higher doses are needed. It is the bodys way of adapting tohaving a foreign substance in the system. People develop a high tolerance to alcohol when they drink a great dealover an extended length of time. WHILE TOLERANCE MAY SEEM TO SOME TO BE ADESIRABLE STATE, IT SIGNIFICANTLY INCREASES THE RISK OF ALCOHOLISM AND LONG-TERMHEALTH AND SOCIAL PROBLEMS. For example, a heavy drinker could still be lucidat 0.25%, whereas the average person would barely be able to function. Even so,the heavy drinker would be extremely dangerous on the highway. Thirteen percent of male and five percent of female college studentsnationwide are alcoholic. Persons are considered alcoholic if they exhibit threeor more of the following symptoms for more than one month, or if the symptomsget repeated over a longer period of time:1.Alcohol is consumed in greater quantities or for longer periods oftime than the person intended; 2.The individual has a persistent desire tocontrol or eliminate drinking, or has made one or more unsuccessful efforts todo this (for example, there are resolutions to cut down, but these effortsdisappear after a period of time); 3.Considerable time is spent in obtaining,using, or recovering from alcohol and its effects; 4.Intoxication or itsaftereffects (e.g., hangovers) frequently occur at times when the person isexpected to fulfill work, family or school obligations; or there is physicallyhazardous use (e.g., while driving); 5.The individual gives up or reduces social,recreational or job-related activities because of alco hol use; 6.Drinkingcontinues despite the knowledge that alcohol causes the person to have social,psychological or medical problems; 7.Significantly increased tolerance hasdeveloped; 8.Withdrawal symptoms occur when initially attempting abstinence(e.g., flu-like symptoms, headaches, gastrointestinal distress, sweatiness, moodswings, irritability, anxiety); 9.Alcohol or other drugs are used to ward offthe withdrawal. Other long-term medical problems include high blood pressure, increasedrisk of heart attack, pancreatitis, various cancers, cirrhosis of the liver. Chronic heavy drinking in men is associated with testicular atrophy and breastenlargement. In women, as little as one drink a day greatly increases the riskof breast cancer. Drinking during pregnancy can cause birth defects and mentalretardation. Alcohol is also fattening. One glass of wine daily added to the diet canresult in a weight gain of ten pounds a year. Cocaine and CrackCocaine is an alkaloid extracted from the leaves of the coca plant. Itis a stimulant and euphoric substance that has powerful effects on the humanbrain. The practice of sniffing (snorting) cocaine actually dates back to thebeginning of this century as knowledge spread about cocaines ability to inducefeelings of well-being and increased energy. At that time, cocaine was alsoavailable in over-the-counter tonics and potions. Crack is cocaine that has been processed so that it can be smoked. It isgenerally sold in small quantities and distributed in small glass vials or smallplastic bags. When crack is smoked, it produces an immediate, short-lived effect. Intravenous use (shooting up) also results in rapid onset of effects, whilethe effects of sniffing are delayed several minutes. The onset of the high, or rush, from cocaine and crack is reported byusers to be intense and pleasurable. Some users have called the rush an orgasmof the brain. The rush lasts only a few seconds, followed by a 20 minute high. Individuals report an increased sense of well-being and self-confidence, alongwith a decrease in fatigue and hunger. Some people report that they experiencecocaine as an aphrodisiac. There is a social aspect to cocaine use as well, ascocaine is frequently obtained from friends and consumed in small get-togethers. Cocaine (and in particular crack) is one of the most addictive drugsknown to humankind. Laboratory studies have shown that animals, when offered theoption to self-administer cocaine, will continue to administer the drug untilthey die, ignoring their needs for food and water. It is reported that as many as one out of every three crack users becomeaddicted to cocaine. There is no scientific way to predict who will becomeaddicted. However, there has been a good deal of news media attention given tostories of successful people who have lost themselves, their jobs, fortunes, andfamilies because of their involvement with cocaine. The problems cocaine causesin peoples lives are so severe and the pull to use the drug again is so strongthat it generally takes people two years of rehabilitation to recover from acocaine addiction, once they seek treatment. Crack is a very rapidly addicting form of cocaine, with addiction oftenbecoming apparent within a matter of weeks. Some users have reported becomingaddicted after their first experience with this form of cocaine. Thus crack isan especially dangerous form of the drug. Food Processing And Preservation EssayRepeated use of the drug produces tolerance (that is, the drug becomesineffective), and it can produce a crash. A recent study found that one of the by-products created when Ecstasy ismetabolized is a toxic substance harmful to nerve endings. This seems to causeParkinsons disease-like symptoms in persons as young as 30 years of age. Thesesymptoms do not appear immediately, but may occur after a period of time. Theyare apparently non-reversible. MushroomsThere are a number of plant materials which have LSD-like effects andwhich come under the heading of mushrooms or shrooms as they are often called. These include the psilocybe mexicana and several other species which have theactive ingredient psilocybin. Mushrooms are generally dried and then eaten. Mescaline originally came form the buttons which grow on the top of peyotecactus. Several varieties of psilocybin mushrooms grow and are illegallymarketed in the Northwest. The initial effects of psilocybin are experienced in 30 minutes and thehigh generally lasts several hours. Small doses can reportedly produce feelingsof physical and mental relaxation and pleasant changes in mood and perception. Larger doses can produce marked changes in perception, with the userexperiencing effects similar to those found with LSD. With mescaline, the effects appear slowly and last from 10-18 hours. Commonly reported effects include euphoria, heightened sensory perception,visual hallucinations, alterations in body image, and some muscular relaxation. With regard to perceptual processes, the unpleasant effects of thesedrugs are similar to those found with LSD. In addition, psilocybin can causedizziness, light-headedness, abdominal discomfort, numbness in the mouth, nausea,vomiting, shivering, facial flushing, sweating, and fatigue. With mescaline,nausea and vomiting frequently occur, and high doses can produce low bloodpressure, cardiac depression, slowed respiration, and headache. These sideeffects have the potential to be medically serious. Both psilocybin and mescaline can be manufactured in the laboratory. MarijuanaMarijuana consists of the dried leaves and flowering tops of the hempplant (cannabis sativa). The plants principal psychoactive ingredient is delta-9 THC (tetrahydrocannabinol). Hashish or hash is the dried resin from the topsand leaves of the female plant. It contains a higher concentration of the THCand is therefore more potent. Both marijuana and hash are usually smoked. When smoked, the effects of marijuana produces a feeling of euphoriawhich gives rise to a tendency to talk and laugh more than usual. Color, sound,and taste, touch and/or smell may be enhanced and experienced as pleasant andfascinating. Muscular relaxation may occur, as well as a sense of well-being andrelief from tension. Cannabis impairs the ability to perform complex motor tasks such asdriving a car. It also impairs short-term memory and logical thinking. At veryhigh doses, effects can be similar to those of hallucinogens, and the user canexperience confusion, restlessness, hallucination, paranoia, and anxiety orpanic. These problems have become more noted in recent years, as the strains ofmarijuana now available are many times more potent than the marijuana of theearly 1970s. Heavy use appears to interfere with brain cell functioning, producingproblems with sequencing ability, time sense, depth perception, memory storage,and recall. Chronic heavy users sometime demonstrate apathy, loss of energy,confusion, and memory problems. Long-term use of THC is also associated with lower sperm counts in malesand alterations in sperm shape and mobility. In women, irregularities inmenstruation and ovulation occur. Pregnant women who are heavy marijuana smokershave higher levels of miscarriages, still-births and genetic disorders. Marijuana smoke contains more cancer-causing agents than tobacco smoke. Laboratory studies have shown pre-cancerous cellular changes in the lung tissueof long term users. Warning SignalsSigns That The Chemical Has Taken ControlThe following symptoms and behaviors, when related to chemical use(including alcohol, of course), indicate that a person has seriouslyoverindulged. Beyond this, these symptoms could indicate a more serious problemor addiction: MEDICALAccidents or injuries Nausea and vomiting Mysterious bruises Gastritis Blackouts (cannot remember something while drinking) Passing out(unconsciousness) Emergency room visitsACADEMIC/EMPLOYMENTAcademic failure/poor work performance Missing classes/absenteeism from work Not living up to ones potential Difficulties with deadlines or procrastination SEXUALImpotence Sexual assault Inability to resist unwanted sexual advance Engaging in sexual activities that are contrary to valuesSOCIAL/PSYCHOLOGICALLoss of self-respect Mood swings Panic and unexplained fears Depression Property damage Paranoia Fights and arguments Social isolation and withdrawalProblems with legal or college authorities Causing emotion al pain to friendsor loved onesDRINKING/USING BEHAVIORSneaking drinks or drugs or using alone Hiding bottles/drugs Consuming morethan intended Inability to predict how much one will consume Using again rightafter sobering up Using to relieve anxiety, insomnia, pain or depression Usingto feel more confident in social situations Spending substantial amounts ofmoney on alcohol and drugs Preoccupation with next high Centering onesrecreational activities around chemicals Family members or friends expressingconcern about ones drinking or other drug use Feeling annoyed or angry whenones chemical use is discussed Inability to carry out an intention to cutdownState LawsThe following chart describes the penalties for POSSESSION of key drugs(the schedules are more inclusive) according to the Federal Drug Schedules:Max. Prison Time Max .Fine SCHEDULE #ClassHeroin, LSD, other hallucinogens marijuana, others 10 years$100,000 SCHEDULE II Class C Felony Methadone, morphine, amphetamines cocaine,PCP 5 years $100,000 SCHEDULE II Class A MisdemeanorsNon-amphetamine stimulants,1 year$2,500SCHEDULE IV Class CMisdemeanors some depressants1 Valium-type tranquilizers, some less potentdepressants 30 days $500SCHEDULE VViolation Dilutemixtures, compounds with small amounts of controlled drugsNone $1,000Delivery of less than five grams or possession or less than one ounce ofmarijuana is a violation. established mandatory evaluation, education andtreatment services for those under 18 years old. If services are successfullycompleted, the charge will be dropped. Alcohol is an illegal drug for those under 21 years of age. For a driverunder 18 ANY detectable amount of alcohol (above .00 BAC) is grounds for losingthe license. That pretty much sums it up for psychodelic drugs. I hope this proved toyou that if you use a psychodelic drug that you should stop, unless it is alcholbecause it is not as bad as LSD, pcp, or anything you have to inject or snort. So I sign out with I hope you learned something, I mean you had to you couldenthave know all of this information. BiblyographyName Year TypeMicrosoft Encarta96EncyclopediaDartmouth collage95Brochure White House97InternetSocial Issues

Friday, November 29, 2019

The Environment, Resources, and Their Economic Effects

Introduction According to Paltseva and Roine (para. 1), natural resources contribute to spending, labor income, and jobs. These resources support numerous jobs and offer employment to the residents of a country. Natural resources and the educated workforce are interconnected and it is of great importance for the state to generate a quality labor force via the attainment of higher education.Advertising We will write a custom essay sample on The Environment, Resources, and Their Economic Effects specifically for you for only $16.05 $11/page Learn More Before the globalization processes started, it was prudent to assume that natural and environmental resources had no competition because resources were in abundance and the economy was using them in an unlimited way. Wealth, jobs, and prosperity were got from these resources via the extractive industries. In turn, the industries converted the resources into commodities. A healthy economy, and a healthy enviro nment could be achieved, but not at the same time. Economic competition was not rife and most of the resources in the environment were free. However, the current scenario predetermines that there is the increased competition for the natural resources that continues to grow. These resources are no longer abundant with the increase in human population that is depleting them. This essay will highlight the economic effects of the environment and the natural resources. The Effect of Resources on the Economy According to Poser (20), natural resources can no longer satisfy the human demands that are placed on them. Therefore, when the resources are allocated to a particular use, other application methods compete with the primary one. It is worth noting that such a trade-off means that the decisions to allocate the resources, like development and protection, generate costs and benefits. They have ramifications for the present and future inhabitants of the nearby communities and the entire r egions. In this paper, it is clear that a natural resource cannot satisfy the demand for the service and goods that it provides. Subsequently, to understand the economic ramifications of the development or protection of the economic resources, one should understand the extent to which it will affect the aforementioned competition.Advertising Looking for essay on business economics? Let's see if we can help you! Get your first paper with 15% OFF Learn More One should keep in mind that the economic value of the natural resources stems from their commercial demands, which entails their development or extraction. The term extraction refers to activities, industries, and the use of resources associated with the production of timber, grazing, mining, and various activities that electrically, physically, or chemically remove several elements from their sources. The term development can be regarded as occupation of a site by structures set up by human beings. This occurs most ly in the event of urbanization. It also entails intense activities by the human beings such as conversion of open land into commercial and housing buildings, the change of the floral community in the forest, the development of recreational sites for the developing industries, and other aspects. The commercial demand for the resources in the environment comes from the public and private enterprises. This is defined broadly to include the groups that sponsor the development and extractive activities. There are two types of demand for the natural resources. First, there is the identification of a specific development, or extractive use of a piece of land that possesses various characteristics. These characteristics can cover the fact that it uses the resources in a direct manner, it depletes the stocks of a number of resources, and that it has a better position compared to the competitors with regard to economic competitiveness (Sarsby and Meggyes 39). Although the identification of a particular use is purposeful, it is arbitrary. This kind of demand is mostly associated with extractive industries such as forestry, mining, and industrial farming. Generally, only a single commercial industry has benefits from some use of the natural resources. In the public domain and protection of resources, the economic significance of various natural resources use is expressed in terms of incomes and jobs for the local populace and profits for the local firms. In several cases, the aforementioned commercial use manifests as the only way for the local residents to derive incomes, profits, and jobs from the natural resources in the area. It is a common event that the extractive or development uses of land are allowed. This translates to gains for the local economy in terms of profits, incomes, and jobs. However, if there is a restriction of these services, then the land will lack a positive influence on the particular economy (Qazi and Qazi 207).Advertising We will write a custom essay sample on The Environment, Resources, and Their Economic Effects specifically for you for only $16.05 $11/page Learn More Measures of Economic Benefits Assessment of economic benefits is achieved through four measures which include labor, income, employment, and value added. To understand these impacts, the principal idea is that the economic impacts of the resources and other economic activities are widespread after assessing the linkages between the various sectors of the country’s economy. This means that the economic activities related to the environmental resources spread the economic benefits via the multiplier effect. Mining and other businesses related to tourism spend money, hire workers in the economy, and this translates to further income and spending. Hence, in the multiplier effect, the economic activities are directly connected to the resource base of the state and are amplified because their hiring and spending in the econo my creates multiple income layers for numerous sectors (Qazi and Qazi 245). The multiplier is an accepted and practiced technique that is used in the assessment of the ramification of business activities in the region. The basis for the calculation of the economic ramification of the environment and the resources via the multiplier effect is an example of the output-input model. The analysis of the economic impacts entails the calculation of the extent to which environmental activities stimulate economic effects. Based on this assessment, the results from the aforementioned model quantify the effects of the cluster of business activities developed around environmental resources (Hackett 340). Although the output-input analysis requires an advanced training on the economy for full understanding of the economic benefits, the elements may be stated in terms that are straightforward. To arrive at the overall economic impacts, economists have to assess the initial effects of purchases an d payroll. The economic effects mentioned above are referred to as direct. Subsequently, the induced and direct effects emanate from the local purchases and the payroll. The aforementioned effects are assessed through various measures, which include the value added, employment, labor income, and the overall economic impact. Total impact refers to the contribution of the resource to the economic activity.Advertising Looking for essay on business economics? Let's see if we can help you! Get your first paper with 15% OFF Learn More It is a measure of the yearly value of services and goods that are associated with business activities, which rely on natural resources. Value added means the general contribution that a resource has towards a country’s economy. Labor income is the contribution that the resource has on salaries and wages. Last, employment is the number of jobs that are associated with the aforementioned economic activities that are tied to the natural resources (Resosudarmo 50). Specific Economic Activities Recreational activities are the ones in which the benefits of the environmental activities can be assessed. Natural resources form the basis for most of the recreational activities in various parts of the world. These resources must be managed and their maintenance should be given the utmost consideration. Hunting, fishing, and wildlife viewing are also activities that are connected to economic impacts. Most regions have departments that ensure the aforementioned activities are catered for based on their economic impacts. Coastal tourism is also an environmental resource that makes immerse economic contribution. Most educated people prefer to reside in areas that have natural resources with high quality. Environmental resources are also sources of amenities, which make working and living in a particular region to be more pleasant (James 35). Unlike the consumer goods that are purchased in specific stores, natural amenities’ consumption is catered for by the federal government or the state. In other locations, regulatory bodies deal with it. Mountains and beaches are environmental resources that help in attraction and retention of the skilled workers in various countries as this is directly connected to economic benefits. Factors for the quality of life are vital factors in the recruitment and retention of the skilled workers and entrepreneurs. The ramification of the natural resources has been confirmed in numerous research studies that tend to look at the inv estors’ choices. Some natural characteristics of a country could enhance its attractiveness. Moreover, to add to the income generated and the local jobs connected with spending on recreation process, it is clear that the amenities engender consumer surplus with regard to the economic value. The surplus is the difference of whatever consumers are willing to pay for the amenities like lakes and beaches and the value that they pay for to enjoy the benefits. Surveys have estimated that the economic value, which consumers place on various types of recreation like camping, hunting, wildlife, and swimming, translates to billion dollars. For countries that are endowed with the aforementioned resources, there is a huge value that reflects high economic benefits (United Nations 142). Forestry is another environmental activity that provides the basis for economic activities. This form of natural resource has widespread economic ramification with activities line logging and forestry amou nting to billions of dollars. These activities rank as the most significant parts of the manufacturing sector. In the direct terms, the forestry industry of the state is the first in employment among the manufacturing sectors in many countries. When the economy is strong, the annual exports from the products amount to billions. Generally, the export of forest products has grown and the exports are poised to attain significant growth in the future. Forestry has had immense impact on the economy of countries that are endowed with the resources because it is a source of employment opportunities (James 20). Minerals are also environmental and natural resources that have an economic impact on a country. Mining activities such as quarrying are rampant in various parts of the world. This results from the endowment of the state with resources that are usable. Quarries and mines extend to various regions and are in the rural and urban areas. The economic impact is huge with mining being a dr iver of the economy in many regions. It contributes to not only the value added but also to numerous jobs connected to the industry via induced, indirect, or direct effects (Resosudarmo 67). Commercial fishing is also another domain in which the economic impact of natural resources can be assessed. In the recent past, various regions have witnessed the transformation of the realm of commercial fishing, which is vital in an economy that depends on resources. Commercial fishing is a business that keeps alive the character of various regions. Presently, it includes a bubbling aquaculture industry in which fresh techniques have created new opportunities for businesses in a number of countries. Commercial fisheries have accounted for millions in revenue (Poser 10). According to the aforementioned findings, natural resources contribute to spending, labor income, and jobs. Natural resources support more jobs and employment offers than any other asset in a state. It should also be mentioned that natural resources and the educated workforce are interconnected and complimentary. On one hand, it is important that a state generates the quality of labor force through the attainment of higher education. The state also has to retain the educated population and this is assisted by maintenance of the integrity of the natural resources. In addition to creation of jobs, natural resources help in preservation of the human capital because of the fact that educated people are mobile in nature, human capital, and amenities are complementary. Amenities like natural resources have a positive influence on the quality of life of a country’s residents. A high life quality means that the residents have a high likelihood of remaining where they are. The natural environment is also influential in maintaining the health of its inhabitants (Poser 20). Individuals benefit immensely from their contact with the nature. Hence, preservation of the natural resources is a part of the health s trategy of a state. Overall, the true value of the natural resources is high. Therefore, they should be considered vital in the development of the economy. The strategy of the state should be to focus on the rewarding business of the natural and environmental resources and enhance the quality of life of the state in the process. Thus, it should be a central part of regional and local economic strategies (Qazi and Qazi 35). A Table Showing How the Economy Depends on Natural Resources Source: Paltseva and Roine Conclusion In summary, the environment and natural resources have a huge economic impact that is felt in domains such as employment, which has a direct impact on the country’s inhabitants’ life quality. The promotion of the natural resources base should be a key in the development policy of all economies. During the time of economic uncertainties, relevant departments need to utilize their resources in promotion of development that can translate to benefits of bu sinesses. Natural resources play a great role in taking such economic decisions. This essay has articulated the economic benefits of the environment and natural resources. It is important for a country to take care of its natural environment because of the accruing economic benefits. Several measures of how natural resources contribute to the economy have been assessed. Works Cited Hackett, Steven C. Environmental and Natural Resources Economics: Theory, Policy, and the Sustainable Society. Armonk: M.E. Sharpe, 2011. Print. James, David. The Application of Economic Techniques in Environmental Impact Assessment. New York: Springer, 1994. Print. Paltseva, Elena and Jesper Roine. Are Natural Resources Good or Bad for Development? 2011. Web. Poser, Nadine. Economic, Environmental and Socio-cultural Impacts of Tourism: An Analysis from Mexico. Munich: GRIN Verlag, 2008. Print. Qazi, Shabir Ahmad and Navaid Shabir Qazi. Natural Resource Conservation and Environment Management. New Delhi: APH Publishing, 2008. Print. Resosudarmo, Budy P. The Impact of Environmental Policies on a Developing Economy. Munich: VDM Publishing, 2010. Print Sarsby, R. W. and T. Meggyes. The Exploitation of Natural Resources and the Consequences: The Proceedings of Green 3 : the 3rd International Symposium on Geotechnics Related to the European Environment Held in Berlin, June 2000. London: Thomas Telford, 2001. Print. United Nations. Decoupling Natural Resource Use and Environmental Impacts from Economic Growth. Stevenage: UNEP/Earthprint, 2011. Print. 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Monday, November 25, 2019

My love Essays - Elena Ferretti, I Wanna Go, Free Essays

My love Essays - Elena Ferretti, I Wanna Go, Free Essays My love, Nothing in this world has ever been more beautiful than getting to lay my eyes on you. Youre the reason I live and breathe. You complete me. You make me the happiest girl in the world. You make me want to buy the world, the moon and the stars, and give it all to you. You make me warm like the summer, mess up your hair, sing out of tune, baby I dont care. You make me want to fly over the world, hold your hand, dance in the rain, linger in your eyes, baby it's insane. You make my world go round, the film strip to my life, the music to my ears and the one Ill make my husband. You make me laugh, you make me smile, you make me me, and see how good life can be. You light up my life, brighter than the sun, fill me full of fun, enter lotteries Ive already won. You make me wanna buy you truck parts, write your name in the diesel smoke on your truck, love you every way I can. You make me wanna swim the sea for one more kiss, hold you for every second of bliss, miss you like Ive never missed. You make me cherish yesterday, love today and live for tomorrow. You pick me up when I fall down, change the direction of any frown, are a prince without a crown. You are my desire, you take me higher, consume me like a fire. You make me drunk off your love, high on your smile, dream of you walking down the isle. You make me wanna see it all said and done, look at us like the lucky ones, live all my life with you the only one. You make me wanna sing more than say, always follow through, listen to your words, the music of my day. You make me forget how to breathe, lose track of time, fall in love, youre more than a dime. You make me wanna love you so, never wanna see you go, teach you all the things I know, yell your name on the radio. You make me wanna fly, you make me wanna soar, you make me wanna hold you forever more. You make me wanna kiss your very core, forget it all, lock the door, stare into the eyes of everything I adore. You make my heart giggle, my butt tickle, and love you the opposite of a little. You make me wanna call you baby, forget about maybe, drive me crazy, youre the craziest man. You make me forget about never, live like forever, love so deep I change the weather. You make me live laughter, immune to disaster, touch my soul, my heart beats faster. I love you forever and ever... happily ever after. Love, Baby Girl 3

Friday, November 22, 2019

Tourism Operations Management Assignment Example | Topics and Well Written Essays - 2000 words

Tourism Operations Management - Assignment Example Improvement in environmental planning and management in the destination including provision of environmental control measures and services such as monitoring and 'improving air and water quality, litter clearance, provision of waste recycling schemes, etc.'; Tourism is a key industry for UK with an annual turnover accounting for over 4% of GDP and with over 7% of the working population working in the sector. As per Department for Culture, Media and Sport (2004), UK is one amongst the top ten world tourism earners. More than 86% of England's tourism income comes from domestic visitors and the sectors that have contributed to the attractiveness of England for domestic tourists, and of Britain for overseas visitors include, transport, galleries, museums, theatres, heritage sites in public and private ownership, conference and exhibition venues, shops, pubs, clubs and restaurants. Positioning of UK as a important destinations rests on meeting and exceeding customers expectations. The priority areas identified by the Government are marketing and e-tourism, product quality, workforce skills, data and advocacy of the case for supporting the tourism industry. Buckingham Palace, the official London residence of Britain's sovereigns since 1837, is a prime tourist attraction. Although many of the official events and receptions are held by The Queen, areas of Buckingham Palace are open to visitors on a regular basis. ... Sustaining tourism enterprises; Prioritising markets that strengthen economic returns; Promoting the use of local products and integration with other sectors; Spreading tourism benefits and opportunities throughout the communities and Strengthening communication with visitors and local residents. The report cites the case of Buckingham Palace, efforts in place and those desired to improve the quality of tourism. Tourism in UK Tourism is a key industry for UK with an annual turnover accounting for over 4% of GDP and with over 7% of the working population working in the sector. As per Department for Culture, Media and Sport (2004), UK is one amongst the top ten world tourism earners. More than 86% of England's tourism income comes from domestic visitors and the sectors that have contributed to the attractiveness of England for domestic tourists, and of Britain for overseas visitors include, transport, galleries, museums, theatres, heritage sites in public and private ownership, conference and exhibition venues, shops, pubs, clubs and restaurants. Positioning of UK as a important destinations rests on meeting and exceeding customers expectations. The priority areas identified by the Government are marketing and e-tourism, product quality, workforce skills, data and advocacy of the case for supporting the tourism industry. Buckingham Palace Buckingham Palace, the official London residence of Britain's sovereigns since 1837, is a prime tourist attraction. Although many of the official events and receptions are held by The Queen, areas of Buckingham Palace are open to visitors on a regular basis. These include the State Rooms, open during the Annual Summer Opening in August and September, which during the 58 days of operation from 31 July to 26

Wednesday, November 20, 2019

Innovation of Emirates 2 Essay Example | Topics and Well Written Essays - 2000 words

Innovation of Emirates 2 - Essay Example Appraisal of the Organization The Emirates Airlines has had a profitable run for a while now, and this calls for an in depth look at the company. This will involve looking at the company’s strengths, weaknesses, opportunities that the company has and the threats that the company has to its profitability. Strengths of the Airline As seen above, the company has managed to be profitable within the economic downturn that has faced many of her competitors. This certainly points to the strength that this company has to its advantage. One strong point of this company is the level of stability in terms of management that the company has. In light with this, the company is able to transact with its clients who have a high level of trust that the company will deliver when it promises to do so. Another upside to the state ownership is the fact the company has a secure source of funding for its existent or future plans. Unlike most other airlines that compete with the Emirates Airlines, t he issue of funding does not bring in as much headache as it does to a lot of her competitors. This is because the state is in complete control of the airline and has a much wider purse with which it can fund the airline’s operations. This, to a large extent explains why the company has been able to remain successful in the long run. The airline is also committed to the use of technology in improving its services. The company has embraced the use of online booking of its tickets as a way of easing congestion as well as improving the overall customer experience. The company has adopted the use of Verified by Visa (VbV) technology (Pan and Polishuk 2004). This is a move that has been calculated to ensure that the airline has a safer mode of transaction with its clients. Aside from that, this technology is also poised to place the airline on a leadership vantage point in relation to its competitors. In addition, this has the advantage of mounting the trust that the clients place on the airline securing their return services. The airline has also strength in terms of the services that it offers to its travellers. The premium customers will get a limousine ride from their homes or office to the airport (Shaw 2011). This action, which is part, of the company’s product differentiation strategy, is calculated to encourage more clients to explore the premium package. This is further accentuated by the services that the clients will get once they arrive at the airport. These services include a kerbside check-in facility to eliminate the hustle of carrying heavy language into the terminal and further a luxurious lounge and ease for the passenger during checking-in (Shaw 2011). This, obviously remove many of the hustles that go with travelling. Therefore, this has had the effect of ensuring that customer loyalty is upheld as well as customer comfort throughout their travel. Weaknesses of the Airline The airline has a number of issues that limit its performan ce. Some of these issues have a lot to do with the ownership and by extension the management of the airline. Accordingly, the government, having full ownership of the airline highly controls the running of the airline’s operations. The government’s say in the running of the airline is a hindrance in many times (Betz 2010). Though the government having a say in the airline is not such a bad thing in the ultimate outlook, it may constitute interference when it decides to overhaul a decision that the airlines’

Monday, November 18, 2019

Business assessment Assignment Example | Topics and Well Written Essays - 3000 words

Business assessment - Assignment Example Recommendations 15 8. References 16 9. Appendix 19 1.0 Introduction Purpose of the Report The purpose of this report is to provide a critical comparative analysis of two organisations in the way they are operated and managed. This is to help us in discovering what causes success or failure for organisations and how different organisations adapt to dynamic environment. Organisations not flexible enough to adapt to the environment are unable to attract and retain talented employees or take advantage of available opportunities hence cannot achieve organisational effectiveness. Scope of the Report To analyse the operation and management of the two organisations the report will consider how they are structured and designed so as to show the interrelationships between roles and departments and lines of authority. Secondly, report will cover organisation of work especially the use of teams and team working. Thirdly, it will analyse the approaches to leadership and management adopted by the organisations as this determines their success or failure. The report will then analyse the organisational culture and its impact on the organisations operations and lastly, conclusions and recommendations will be made on how to improve operations and management. Organisations Background Biogenta is a manufacturing company producing crop-protection products and whose mission is to be the most trusted provider of crop-protection products in the world. It has manufacturing facilities in 10 countries and employees in over 80 countries. Contrary to popular belief that large size companies are bureaucratic in nature, Biogenta has an organic structure and a matrix design where individuals belong to a functional area and a project team. The chief executive officer, Jane Morgan is an effective leader and manager whose encouragement of creativity and innovation has pushed the company to greater heights. The company has a very strong culture which emphasizes on learning and development, diver sity and corporate social responsibility. Outback Inc is a traditional organisation run by family members. It offers tourism services to wide range of clients and operates in a very turbulent environment. Being a small organisation, it is expected to have an organic structure but instead, it is bureaucratic in nature with a functional design and little or no teamwork. Creativity and innovation is hindered by its autocratic leadership style. The company has no vision or mission and has a high turnover culture due to lack of opportunity for advancement and employee voice. 2.0 Organisational Design and Structure Benowitz (2011, p.70) defines an organization structure as â€Å"the configuration and interrelationships of positions and departments†. An organisation design on the other hand, is the change of an organization structure to enable it to respond effectively to environmental changes. A poor organization design and structure can lead to lack of co-ordination among function s, slow decision making, and role confusion (Corkindale, 2011). Types of Organisation structure An organisation structure is determined by the degree of complexity, formalisation, and centralisation. Complexity reflects the amount of differentiation in an organisation; formalisation shows the degree to which an organisation uses rules and procedures to direct behaviour while centralisation reflects how power and authority is distributed in an organisation. Gitman and McDaniel (2008) recognise two kinds of

Saturday, November 16, 2019

Strategic Management And Decision Making

Strategic Management And Decision Making When the benefits of actions are predictable, when the forces or variables that drives the firm are known and move in deterministic manner, when the deviations arent high , one can easily use standard decision making optimization techniques. But when the situations are unpredictable, forces are unknown and move in unpredictable and non-linear manner, and then optimization principles will not help much. And this is what we are facing today. The utter necessity of tactical, operational and strategic approach is the solution to such dynamic situations that can be achieved through making important decisions strategically. CHARACTERISTICS AND APPROCHES TO STRATEGIC DECSION MAKING Unlike routine decisions, strategic decisions are highly substantial and significant that has pervasive and long term effect on an organization life. Such decisions must have following characteristics to be considered as a direction for future actions throughout an organization, these are: Rare: Strategic decisions are rare and unusual and do not have any example or model to follow. Consequential: Since strategic decisions are substantial, therefore its demands lot of dedication from people at all levels. Percussive: Good strategic decisions serve as a role model and set standards for upcoming decisions in future. Also as stated by Cyert and March(1963) that in established organization, the scope for decision making is limited by prior decision, either explicit or implicit, as well as being limited by morally committed to resources and departments etc. According to Thompsons (1967) decisions has 2 major dimensions i.e. preference about possible outcomes and cause and effect relations. And the degree of certainty and uncertainty is defined by causation and outcome preference, as shown in figure below: Fig.1 Situation Certainty Uncertainty Certain Computational Compromise Uncertain Judgmental Inspirational Computational Decision Making: Computational decisions are the outcomes of linear relation between causation and preferred outcomes. For examples, if company wishes to increase its sales by 2%, it must increase its advertisement by 4% , and for 4% sales, it must increase advertisement by 8%, knowing linear relation exists between cause and effect. Thus increasing advertisement increase sales by double and this is called programmed decisions by Simon(1997). Judgmental Decision Making: It occurs when cause and effect relation is uncertain, but outcome preference is certain. For examples a company targets to increase its sales by 2% for the coming year, but is uncertain about how to much increase advertisement to reach such target. So some kind of experienced powerful individual of committee with high intuition is required for effective decisions. Compromise Decision making: Compromise decisions are the outcomes of situations where there is certainty about causation and uncertainty about preferred outcomes. From previous examples, if company knows from its historical data that for every 2% increase in sales, the advertising must be increased by double, this is causation certainty, but there is uncertainty about achieving desired goals with respect to increase in sales. Inspirational Decision Making: Such decisions are the outcomes of both uncertainty about cause and effect as well aS preferred outcomes. For an instance, a company isnt sure that how much advertising percent be increased to get certain percent of sales increment. So for such cases a entrepreneurial mode or well planned mode is required to make careful decisions. Because of uncertain business environment, decision makers face difficulty matching probability with outcomes, having many decision tools in hand. However, again despite of having such tools, lack of accuracy is also one of the biggest obstacles in making decisions strategically. In short we can summarize typical problems involved in strategic decision making are: Uncertainty: Dealing with excessive complexity and rapid changes Self-fulfilling prophecies: Coping with situations that external factors arent fixed, but are affected by decisions. Fragmentation: Working to connect regional functional groups. According to Mintzberg, there are different approaches to making strategic decisions, that could be done by one person or by team. Entrepreneurial Mode The strategy is developed by one individual with strong entrepreneurial capabilities, supported by the owners vision of direction. It is a good example of availing the available opportunities. Example AOL, Amazon.com. Adaptive Mode Unlike entrepreneurial mode, adaptive mode is the focus on the threats posed by external conditions, rather than search for opportunities. Planning Mode Planning mode is the combination of both entrepreneurial mode and adaptive mode, which consist of proactive search for opportunities and reactive solutions to current problems. It is a typical form of decision making where set alternatives strategies are presented and the best are chosen and implemented. Logical Incrementalism This philosophy of decision making is characterized by achieving organizational objectives by disseminating large organizational objectives into small steps for better focus. Though it is time consuming, but offers greater flexibility. STEPS IN STRATEIC DECISION MAKING PROCESS One of the distinguishing factor of strategic decisions from other decisions is context in which decision is made. The figure below represents this context in 3 Cs form i.e. Company, Competitor and Customer. This means that managers ( company) make decision within organizational context ,with influence from other players like customers and competitors .Thus we can say that managerial strategic decision is outcome of number of players like manager himself, customers, competitors, public, media etc. As we can also see from figure that many factors, both external and internal are involved in strategic decision making. There are modifiers, influencers, and controllers and so on that decides the viability of decision making. As mentioned before that most appropriate approach to strategic decision making is Planning mode, because it is more analytical, flexible in dealing with complex and changing environment, and consist of presenting set alternative strategies in response to solution for existing problems or looking for new opportunities. Following are the steps involved in strategic decision making process, shown in fig. 4 Evaluate current performance result: The first step in decision making is (a) evaluating current performance of the company in terms of various measuring tools of decision making i.e. NPV, ROI, profitability etc and (b) evaluating the current mission, vision, strategies and policies of the organization. Review corporate governance Assess the performance of the organizations board of directors and top management, and agency head. Scan and assess the external environment Analyze the external environment. i.e. Societal and Task environment, for opportunities and threats and weigh external strategic factors. Scan and assess the internal environment Analyze the internal environment i.e. organization Culture, Structure and Resources for example programs, IT needs, constraints and weigh strategic factors in terms of strengths and weaknesses. Analyze strategic (SWOT) factors Consider strategic factors in light of current department situation and review and revise the firms mission, vision, strategies and objectives. Generate, evaluate and select the best alternative strategy Keeping in view the previous step of analyzing strategic factors, operate and evaluate strategic alternatives and options and choose the best feasible options. Implement selected strategies Once the strategies are chosen, the next important step is to implement them keeping in considerations factors like budget, resources etc. Evaluate implemented strategies This is a very important step in decision making to check for any deviation from actual desired and pre- planned outcomes. CONCLUSION Strategic management is one of the very important areas in business environment and making decisions strategically is one of the biggest challenges in todays rapidly changing and complex environment. Strategic decision making is a process of generating alternatives and choosing the best feasible alternatives for achieving long run objectives of the organization. Good strategic decisions are rare, consequential and directive, that set standard for future actions. The context in which the decisions are made is very important, as mentioned; it is external players like customers, competitors, media etc along with internal input from managerial efforts that effect quality of decisions. And also it is very important to know how these factors influences the quality and effectiveness of strategic decision making and be proactive to convert threats into opportunities, rather than being re-active in finding solutions to current problems. REFERENCES http://www.dol.gov/cio/programs/ITStrategicPlan2006/decisionmakingprocess.jpg http://www.stratrisk.co.uk/about/execSummary/fig3x470x345.jpg http://en.wikipedia.org/wiki/Strategic_management http://books.google.ae/books?id=c35YVifvGekCprintsec=frontcoverdq=strategic+decision+makingsource=blots=EPD5PfXGS-sig=WcXC9bk8R0bxKf1TZpZriuic-Ashl=enei=kLUhTKazFsaLONHUiTosa=Xoi=book_resultct=resultresnum=1ved=0CBYQ6AEwAA#v=onepageqf=false Raghbir S. Basi, University Professor of Management and Glenn and Eva Olds Professor of International Understanding, Alaska Pacific University, Anchorage, Alaska, Administrative decision making: a contextual analysis http://en.wikipedia.org/wiki/Strategic_management#cite_note-79 Understanding Managers Strategic Decision-Making Process, WILIAM BOULDING ~ Fuqua S «hool of B «Ã‚ «siness, Duke Universitv Box 90121, Durham, NC 27708-1020 Retrived from URL : http://www.springerlink.com/content/rg6770h0148641l7/fulltext.pdf (Mulcaster, W.R. Three Strategic Frameworks, Business Strategy Series, Vol 10, No1, pp68 75, 2009) Our book Wheelen T.L ( ) and Hunger J. D Strategic Management and Business Policy Strategic decision making : Applying The Analytical Herarchical Process Navneet Bhushan and Kanwal Rai Retrieved from URL http://books.google.ae/books?id=c35YVifvGekCprintsec=frontcoverdq=strategic+decision+makingsource=blots=EPD5PfXGS-sig=WcXC9bk8R0bxKf1TZpZriuic-Ashl=enei=kLUhTKazFsaLONHUiTosa=Xoi=book_resultct=resultresnum=1ved=0CBYQ6AEwAA#v=onepageqf=false

Wednesday, November 13, 2019

Where Has My Job Gone? Essay -- Employment India Essays

Where Has My Job Gone? With the implementation of minimum wage and rising production costs in the United States, many companies have found themselves looking for a way to save money on production. Clothing manufacturers such as Nike have used labor forces in other countries, mainly in Asia to produce their products. These countries can offer similar quality labor for a cheaper cost on wages. The lower or non existent minimum wage laws in foreign countries allow companies like Nike to cut production costs drastically, while still being able to produce quality products. Similar trends are starting to creep into software companies. They are finding a workforce able to do similar work as the American workers, but for less pay. These companies are outsourcing their work. Outsourcing is simply the transfer of operational responsibility of either business processes or infrastructure management to an external service provider. [1] The majority of these jobs end up in India due to their low wages and high l evel education. Why would companies outsource? Companies look to outsourcing software because of the many benefits it provides. Most noticeably is the savings on costs it can provide. The lower costs over in Asia, especially India, help to reduce and control costs. The production costs are lower because of the lower wages of the workers in India. The average yearly salaries for IT programmers were $5,880 in 2002 compared to the $63,331 US programmers were making. [2] The difference is that labor in India costs about 9% of the costs of the US labor. Furthermore, by outsourcing software work to India, companies can use their existing personnel for different projects. The US workers can be put on tasks that c... ...r, 2003. The International Herald Tribune Online. 16 March 2014. . [7] †Advantage of Outsourcing to India.† VT Consulting. 16 March 2014. . [8] Rayen, Ranjeet. â€Å"ITPL to become role model for Bangladesh’s hi-tech park.† 19 June 2001. GlobalOutsourcing.org. 16 March 2014. . [9] Pink, Daniel. February 2004 â€Å"The New Face of the Silicon Age.† Wired. Issue 12.02. 16 March 2014. . [10] Adam Smith. An Enquiry into the Nature and Causes of the Wealth of Nations (1776), reprint, ed. Edwin Cannan (New York: Modern Library), 1937, p. 14.

Monday, November 11, 2019

Organization and Culture Essay

Provide a brief (one 1 paragraph) description of the organization you chose to research. The company that I chose to research is the company Google. Everyone is aware of Google. It is the most widely used search engine in the world. Google is considered to be one of the best, if not the best search engine of all time. The company Google is considered to be a technological giant and a threat to other tech giants, for example Microsoft. Google’s creators Larry Page and Sergey Binn, started this company in 1995. Google was first developed to be a search engine, but it has crown to the point where it can be used as an internet browser also. Unlike its competitor Microsoft Internet Explorer, it has to be compatible with certain browsers in order to function at its fullest potential. Examine the culture of the selected organization. Google’s corporate culture began with its founder’s philosophy, the famous 10 tenets. (Lisa Jackson 2013). And since Google is still controlled by its founders, that means that the culture in part of the company’s mantra. Google’s founders Larry Page and Sergey Binn believe that trust is one of the most important aspects for the culture at Google. Google mission is a culture of choice. That is they are not a conventional company in the sense that they are not a slave to Wall Street, and that allows them to build a culture that will deliver on this mission and that is principally organized to drive innovation. (Jeff Jarvis, 2013). Because of this trust that Google foster’s to their employees, they are allowed to take risk, while being innovative. And with innovation comes feedback and collaboration. With this type of corporate culture at Google, their employees are much more enthusiastic about the ideas that they present to the founders. There is not right or wrong way at Google, they are visionaries and as such can implement and idea, and if it works, that fantastic, if the idea does not work, then  back to the drawing board. Again, it all stems from the trust ideas from the founders. Google’s culture is very unique. At Google, they believe that if you focus on the user, all else will follow. They also believe that democracy on the web works and also that there is always more information out there. These are three out of the ten tenets that the founders of Google stand by. With these types of statements from one of the largest technological companies, it is no wonder that Google is considered the number 1 place to work in the United States. It’s because the founders allow the staff to develop ideas, make mistakes and they celebrate the failure instead of reprimanding or terminating the staff. This seemingly laid back culture fuels the imagination of the staff and gets them always looking for ways to improve not just the company, but themselves as well. Explain how you determined that the selected organization showed the signs of the culture that you have identified. When I decided to do rese arch on Google, and their culture, I decided to look at why this company is considered one of the best places to work in the United States. I asked myself, why is this company so popular? Why are their employees always happy? First you look at the culture. The founders believe in letting their employees be free to be innovative. They have a t-shirt and jeans work atmosphere, freedom to make mistakes and start over again, etc. This is only part of the culture. Another aspect of the Google environment is ensuring that their employees are adequately compensated. Their benefits are also excellent. Google’s employees enjoy free health and dental, free breakfast lunch and dinner. They also have an organic chef that caters to the needs of the employees. Google found that women were leaving the company at twice the rate of everyone else. In particular, this occurred with new mothers. Google’s maternity leave plan was 12 weeks paid time off. Human Resources changed the plan so new mothers could get 5 months paid time off with full pay and benefits. They were allowed to split this time up however they want. The result after the change in policy? A 50% reduction in attrition for new mothers. Google tries to hire and retain the best employees. They do this based on data. When this data is collected, they u se this information to gauge employees and improve their productivity.   Determine the factors that caused the organization to embody this particular culture. For Google, it seems as if the corporate culture that they have right now is doing just  fine. Google was name the top place to work in 2012. But if for some reason, they did decide to change their corporate culture, I think it would be to continue to enhance on the 10 tenets that was there from conception. Of course as time, and concepts changes over time, innovators such as Larry Page and Sergey Brinn will have to change as well.But, with a new CEO, Larry Page who is excited about leading the team into product development and technology strategy, but also keeping the core of the company for what it was when they first started. Google is efficient and effective. Fortune magazine reported that Google does more business than their entire competitor combined, plus they do it at a lower cost. Because Google has a casual and democratic atmosphere, resulting in its distinction as a â€Å"Flat† company. The company does not boast a large middle management, and upper management is so hands on, it’s hard to qualify them in a separate category. Teams are made up of members with equal authority and a certain level of autonomy is maintained.   Determine what type of leader would be best suited for this organization. Support your position. The type of leader that would be best suited for Google is a Transformational Leader. Transformational leadership is a type of leadership style that can inspire positive changes in those who follow. Transformational leaders are generally energetic, enthusiastic, and passionate. Not only are these leaders concerned and involved in the process; they are also focused on helping every member of the group succeed as well. Through the strength of their vision and personality, transformational leaders are able to inspire followers to change expectations, perceptions, and motivations to work towards common goals. They have the ability to garner trust, respect and admiration from their followers.   Imagine that there is a decline in the demand of products or services supplied by the selected organization. Determine what the change in culture would need to be in response to this situation. If for some reason there is a decline for the products and services supplied by Google, I think that the founders will continue to have the same culture that they originally started the company with. And I say that because, so far that culture seems to be what has Google as one of the top tech giants in the world. Of course, the founders Larry Page and Sergey Binn, being the visionaries that they are, as times and concepts changes over time, they will have to change as well. They will always have to be one  step ahead of the competition, if intend to last in the technological game. References The Real Secret of Google’s Corporate Culture: by Lisa Jackson, July 2013. https://www.web-ebschohost-com.libdata.strayer.edu/ehost/deliveryArticle: Refreshing Google. By: Saporito, Bill. (2011) Vol. 177 Issue 5, p48-49. https://www.web-ebschohost-com.libdata.strayer.edu/ehost/deliverySearch and Destroy. (Cover Story) Authors: Vogelstein, Fred. Source Fortune 5/2005 Vol. 151 Issue 9, p72-82. (Article) https://www.web-ebschohost-com.libdata.strayer.edu/ehost/deliveryThe Real Difference between Microsoft and Google by: Dana Blankenhor (February 2008) http://www.corporateculturepros.com

Saturday, November 9, 2019

10 Things You Shouldn’t Do When You’re Broke

10 Things You Shouldn’t Do When You’re Broke Whether being broke is a permanent state for you, or you’re just passing through a bit of hardship, there are a few lifestyle adjustments it would be prudent for you to make in order to not end up in a mountain of debt. Being broke is also incredibly stressful- you’re constantly worried about your bank balance and how you’ll afford necessary purchases. Why add to the stress?Here is a list of good things to avoid doing if you’re having trouble making ends meet.1. SmokeSeriously. Apart from the fact that it will eventually give you cancer (aka huge medical bills), it’s incredibly expensive to keep up. You’ll live longer and find you have a lot more spending money week to week.2. DrugsDon’t smoke anything else either. People can tell and won’t hire you. You’ll have to constantly worry about passing random or job-related drug tests, and you’ll be spending a lot of money you just don’t have.3. Join a GymFitness i s a great thing, but can be achieved much more cheaply than by getting a monthly (spendy) gym membership. Go running. Do push-ups and crunches. Try the Scientific 7-Minute Workout. Find yoga videos for free on YouTube. Figure out how to exercise for free- it’s super simple these days.4. Look Down on WorkAs long as someone’s job is legal and ethical, it’s no business of yours to look down on it. Maybe you should even consider the service industry. Answer phones, wait tables, clean houses. Just get yourself back on your feet.5. Make ExcusesChances are it’s your responsibility. Unless you’re caring for a sick loved one or facing enormous medical bills yourself, you probably were just living beyond your means. Own the position you’re in and take action to dig yourself out of your financial hole.6. Take Unnecessary VacationsIf you can’t keep up with your rent or car payments, then whatever extra cash you think you have for trips or weekend s away should probably be put to more constructive use. Don’t be flagrant when you can’t afford to be.7.  Go Out to EatAvoid restaurants. You can’t afford them. Seriously. Cook for yourself and bring your lunch- leftovers are your friend. That goes for buying coffee as well; get to know your Mr. Coffee- your new regular coffee shop! If you must go to a movie, smuggle cheaper snacks in in your handbag instead of shelling out for concession prices.8. Upgrade Your StuffNow isn’t the time to get a nicer car or move to a nicer neighborhood. You can’t afford the extra cash you’d need to get this done- or the loan payments. Stick with your station for a while longer until you can afford to move up.9. Ignore the BillsYou may cringe whenever a new pile shows up in the mail, and want to hide under the covers and hope that all your bills just go away. But they won’t. Open them. Call the companies. Set up payment plans. Be proactive. It’ s much better than blissful ignorance- which can still eat you alive with stress.10. Create WasteDon’t drive anywhere further than you have to. Consolidate errands to consolidate gas. Don’t go on lavish dates- simple ones will do and are often more romantic anyway. Don’t waste water or gas or electricity in your home. Don’t pay to do anything you could do yourself (car washes, house cleanings, lawn mowing). And don’t take on any extra expenses that aren’t absolutely necessary. Actually reading that magazine? Probably not. Cancel cancel cancel.

Wednesday, November 6, 2019

Your Discussion Section 4 Things to Remember - Proofed

Your Discussion Section 4 Things to Remember - Proofed Your Discussion Section: 4 Things to Remember When writing a master’s thesis or PhD dissertation, it’s easy to lose track of what you’ve done. This is why it’s important to plan your paper properly. Referring back to what you’ve already done is especially vital when discussing the results of your research, as it isn’t enough to simply describe your data. You also need to relate your results back to your original hypothesis and your literature review, which will help clarify the significance of your work. At Proofed, we’ve noticed that many overlook their literature review in the discussion section. But since this can seriously affect the clarity of your work, we’ve compiled the following list of four things to remember when discussing the results of your research. 1. Use Your Literature Review to Contextualize Your Work The main purpose of a literature review is to contextualize your work as part of an existing debate. Don’t forget this when it comes to discussing your results, as the overall significance of your research will depend on how you have engaged with past research. 2. Compare Your Results with Existing Studies Do your results agree or conflict with the past studies you’ve examined? If there’s a difference, why might this be? Comparing your results with past studies is a great way to connect your research with the existing debate. It can also provide the basis for the conclusions you draw from your results. 3. Understand the Limitations of Your Work The discussion section of your paper should include some acknowledgement of the limitations of your study (e.g., in terms of scope or the methods used). If you have critically analyzed similar studies in your literature review, you can compare your work against their strengths/weaknesses. 4. Don’t Be Afraid to Tweak Your Literature Review The focus of your research may change over time when working on a long-term project. This is normal. The key thing is to adjust the focus of your literature review to reflect these changes. When discussing your results, for example, if you notice certain themes or trends are more prominent than others, it’s often helpful to revisit your literature review to emphasize these same themes/trends there too. If you follow this advice you should find it much easier to communicate your ideas clearly when writing up your dissertation/thesis. But to make completely sure your writing is up to scratch before submission, it’s a good idea to have one of the experts at Proofed check your work. Try sending a 500-word sample to be proofread for free today.